By Eveline S. Litscher, Paul M. Wassarman

ISBN-10: 0470528117

ISBN-13: 9780470528112

ISBN-10: 1119044723

ISBN-13: 9781119044727

ISBN-10: 1119044766

ISBN-13: 9781119044765

ISBN-10: 1119044995

ISBN-13: 9781119044994

This e-book offers a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical details on hand for the zona pellucida area protein family members, which impression pathologies reminiscent of infertility, deafness, and melanoma. in addition it:

  • Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
  • Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
  • Speculates as to the evolution of the ZP area and strength therapeutics for ailments stemming from ZP area mutations
  • Addresses mammalian and non-mammalian systems

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Additional resources for A Guide to Zona Pellucida Domain Proteins

Example text

Zhao M, Gold L, Dorward H, Liang L et al. Mutation of a conserved hydrophobic patch ­prevents incorporation of ZP3 into the zona pellucida surrounding mouse oocytes. Mol Cell Biol 23, 8982–8991 (2003). 4 Structure of the ZPD As mentioned previously, the ZPD is a bipartite structure consisting of two sub‐ domains, ZP‐N and ZP‐C, linked by a protease‐sensitive region. However, ZP‐N can serve as an independent structural domain since it is present in ZPD proteins Plac1, Oosp1, and papillote in the absence of the ZP‐C sub‐domain.

Further Reading Bleil JD, Wassarman PM. Structure and function of the zona pellucida: identification and ­characterization of the proteins of the mouse oocyte’s zona pellucida. Dev Biol 76, 185–202 (1980). Boja ES, Hoodbhoy T, Fales HM, Dean J. Structural characterization of native mouse zona pellucida proteins using mass spectrometry. J Biol Chem 278, 34189–34202 (2003). Bork P. A trefoil domain in the major rabbit zona pellucida protein. Protein Sci 2, 669–670 (1993). Callebaut I, Mornon JP, Monget P.

Mammalian ZP proteins, tectorin‐α, and uromodulin). It is likely that ZP proteins are derived from a common ancestral gene. 2). 7), amphibians, and birds. The absence of ZPd and ZPax in mammals suggests that these genes have been lost during evolution. Accordingly, mammals have three to four ZP genes, amphibians have five ZP genes, and birds have six ZP genes. Since more and more DNA sequencing data has become available, a better understanding of the genetics of the ZP has emerged. , mZP3 vs.

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A Guide to Zona Pellucida Domain Proteins by Eveline S. Litscher, Paul M. Wassarman


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