By R. Steiner (auth.), Dr. Rudolf Steiner, Dr. Paul B. Weisz, Dr. Robert Langer (eds.)

ISBN-10: 3034870019

ISBN-13: 9783034870016

ISBN-10: 3034870035

ISBN-13: 9783034870030

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B p .... 5 .... 0 50 Morphometric data The angiogenic activity should be manifest as a change in vascular density. Since this parameter can be of direct and indirect decisive consequence for the viability of a tissue, the percentage of necrotic vs viable regions was determined in light microscopic sections apart from the number of perfused and functionally compressed vessels. Figure 13a shows the number of vessel per mm 2 of the squamous carcinoma as a function of time. Despite large ranges of deviation, there was a general tendency for a decrease from an initially high to a low value and which is also reflected by the number of perfusable vessels.

G. ). The forthcoming development of polymers as cell or organoid carriers in combination with angiogenesis factors [6, 7] opens up a vast field for imaginative ideas in research. The 31 same is true for the pathophysiological processes occurring in traumatology be it in soft tissue or bone, where angiogenesis may be a functional tool in combination with biodegradable osteosynthesis. The role of angiogenesis factors in the reestablishment of circulation in all types of muscles - myocardial or other - either in combination with new laser techniques or with electrical and magnetic transportation is another challenging prospect.

To address these problems, small polymeric systems have been developed that can release proteins such as angiogenesis inhibitors for weeks or even years. These systems have been used in rabbit cornea as well as the chick chorioallantoic membrane (CAM) to study the angiogenic response. They provided some of the earliest methods by which angiogenesis stimulators and inhibitors could be studied in bioassay systems. It is of note, however, that the first biocompatible systems to deliver peptides or proteins were developed because of angiogenesis research [1, 2].

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Angiogenesis: Key Principles — Science — Technology — Medicine by R. Steiner (auth.), Dr. Rudolf Steiner, Dr. Paul B. Weisz, Dr. Robert Langer (eds.)


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